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Now, today if you'd like to donate, we have a "donate" button on the Myeloma Crowd site and you can help us start to donate for this very unique endeavor. The specific projects will come later as we allow time for these full proposals and all the shows to be completed. Now, we are very privileged today to have with us Dr. Bruno Paiva of the University of Navarra in Spain. And because Dr. Paiva is joining us from Spain, we may have a little delay until he joins us, so I'm going to give us a little introduction for Dr. Paiva. Dr. Paiva is Scientific Coordinator of the Flow Cytometry Department and CIMA Lab Diagnostics group at the University of Navarra in Spain. He teaches courses regularly on cellular biology, techniques of quantification and analysis, new treatments in hematological cancers, inflammation as it relates to the blood and minimal residual disease. The Spanish group with which he has worked has performed very extensive work appreciated by the entire myeloma community and myeloma practitioners on the flow cytometry test as it relates to minimal residual disease. He specializes in understanding the heterogeneity or biological complexity of MGUS, smoldering myeloma, active multiple myeloma and how it evolves. He is involved in both the detection and classification of myeloma and has written numerous papers on the topic, writing or speaking on the subject over 140 times. He's also been Primário Investigator on clinical trials utilizing immunotherapies including the SAR650984 anti-CD38 monoclonal antibody. He participates as ad-hoc reviewer for Blood Cancer Journal, Blood, Pathobiology, Leukemia
Automated identification of leukocyte subsets improves standardization of database-guided expert-supervised diagnostic orientation in acute leukemia: a EuroFlow study
Breeze is Valorant’s sixth map, set on the Caribbean coast near the Bermuda Triangle. Don’t get confused into the conspiracy theories though: The expansive map is actually pretty easy to break down. We’ve got your one-stop guide right here to master Breeze.
A large meta-analysis establishes the role of MRD negativity in long-term survival outcomes in patients with multiple myeloma
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Dr. Paiva: Those I believe, Jack, are two different questions. Regarding the first -- and again, looking into the outcomes we had with the initial follow-up, but of more recent clinical trials, it seems that the outcome of patients with high-risk disease reaching MRD negativity is indeed superior as compared to the outcome of patients with standard risk disease and not reaching MRD negativity, in other words, remaining MRD positive. That would be the answer for your last question. Regarding the first question, absolutely equally important is to characterize the biology. The genetic landscape of ultra chemo resistant cells from high-risk patients will be also to do the same approach in standard risk patients, also to understand the difference in the genetics of chemo resistance between the two patient cohorts, so this would be crucial. Also, and this should also be a research priority to all myeloma scientific groups, as you are probably aware that depth of a response is a key prognostic factor, but it does not afford the same answer to all the patients.
That said, MRD assessment in these pts was not performed with next generation techniques nor or in later time points. Additional discordances have been identified between multipar...
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Steven Soderbergh, Derivado do el final polé especialmentemico do los Oscar 2021: "los discursos do los actores tienden a ser más dramáticos"
After conferring with pro players globally, in the interest of competitive integrity, Breeze has been removed from the map rotation at Masters Reykjavik.
If we confirm there is a class II MHC deficiency immunodeficiency in CFS/ME patients, it would allow a diagnostic protocol using immunological markers. This would help to link the infection of intracellular pathogens with this type of immunodeficiency.
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Cynthia: Okay, so for the resistant cells of those high-risk myeloma patients that you tested for MRD, you're going to start probing them and looking for some biomarkers that might be on those cells that maybe people who don't have high-risk myeloma or have leftover disease don't have those biomarkers.